Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression
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چکیده
منابع مشابه
Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons.
Neurons that express pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) in the arcuate nucleus of the hypothalamus suppress feeding and increase energy expenditure in response to circulating adiposity signals such as leptin. Alterations in gene expression may lead to long term modification of this circuit and alterations in body weight. Therefore, understanding...
متن کاملPeptides that Regulate Food Intake Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
Bi, Sheng, Benjamin M. Robinson, and Timothy H. Moran. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285: R1030–R1036, 2003. First published July 3, 2003; 10.1152/ajpregu.00734.2002.— Although acute food deprivation and chronic food restriction both result in body weight loss, they produce diffe...
متن کاملInhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression
Hypothalamic glucosensing, which involves the detection of glucose concentration changes by brain cells and subsequent release of orexigenic or anorexigenic neuropeptides, is a crucial process that regulates feeding behavior. Arcuate nucleus (AN) neurons are classically thought to be responsible for hypothalamic glucosensing through a direct sensing mechanism; however, recent data has shown a m...
متن کاملOver-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
Diet-induced obesity (DIO) in rodents is characterized by impaired activation of signal-transducer and activator of transcription 3 (STAT3) by leptin receptors (LepRb) within the hypothalamic arcuate nucleus. This signaling defect likely plays an important role in development of DIO. However, the neuro-chemical identity of the leptin-STAT3 resistant arcuate neurons has not been determined and t...
متن کاملNPY Y1 receptor is involved in ghrelin- and fasting-induced increases in foraging, food hoarding, and food intake.
Fasting triggers a constellation of physiological and behavioral changes, including increases in peripherally produced ghrelin and centrally produced hypothalamic neuropeptide Y (NPY). Refeeding stimulates food intake in most species; however, hamsters primarily increase foraging and food hoarding with smaller increases in food intake. Fasting-induced increases in foraging and food hoarding in ...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2016
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2016.1215382